Methoxyflurane
It is highly nephrotoxic
a. Part is metabolized by beta-lyase
b. More than 30% is metabolized by liver producing large amounts of inorganic fluoride – Fl–
No longer used
Ethyl chloride
Explosive / under pressure
It is explosive in nature and has a very low boiling point, so kept under pressure in cylinders.
Use – local anesthetic – cooling
It has cooling property when applied locally.
It is used in cryosurgery for local application.
Trichloroethylene
Analgesia
More analgesic property than anesthetic.
Soda lime
Use is very limited as interacts with soda lime in machine, producing toxic metabolite.
Chloroform
It has been very popular in past, now safer and efficacious agents are available. It is still used in animals.
Disadvantages:
a. Breath holding
b. Hepatotoxic
c. CVS depressant