4. Metabolism, Catabolism and Anabolism

A summary of metabolism

The unity of life

At the cellular level of organization, the main chemical processes of all living matter are similar, if not identical. This is true for animals, plants, fungi, or bacteria; where variations occur (such as, for example, in the secretion of antibodies by some molds), the variant processes are but variations on common themes. Thus, all living matter is made up of large molecules called proteins, which provide support and coordinated movement, as well as storage and transport of small molecules, and, as catalysts, enable chemical reactions to take place rapidly and specifically under mild temperature, relatively low concentration, and neutral conditions (i.e., neither acidic nor basic). Proteins are assembled from some 20 amino acids, and, just as the 26 letters of the alphabet can be assembled in specific ways to form words of various lengths and meanings, so may tens or even hundreds of the 20 amino-acid “letters” be joined to form specific proteins. Moreover, those portions of protein molecules involved in performing similar functions in different organisms often comprise the same sequences of amino acids.

There is the same unity among cells of all types in the manner in which living organisms preserve their individuality and transmit it to their offspring. For example, hereditary information is encoded in a specific sequence of bases that make up the DNA (deoxyribonucleic acid) molecule in the nucleus of each cell. Only four bases are used in synthesizing DNA: adenine, guanine, cytosine, and thymine. Just as the Morse Code consists of three simple signals—a dash, a dot, and a space—the precise arrangement of which suffices to convey coded messages, so the precise arrangement of the bases in DNA contains and conveys the information for the synthesis and assembly of cell components. Some primitive life-forms, however, use RNA (ribonucleic acid; a nucleic acid differing from DNA in containing the sugar ribose instead of the sugar deoxyribose and the base uracil instead of the base thymine) in place of DNA as a primary carrier of genetic information. The replication of the genetic material in these organisms must, however, pass through a DNA phase. With minor exceptions, the genetic code used by all living organisms is the same.

The chemical reactions that take place in living cells are similar as well. Green plants use the energy of sunlight to convert water (H2O) and carbon dioxide (CO2) to carbohydrates (sugars and starches), other organic (carbon-containing) compounds, and molecular oxygen (O2). The process of photosynthesis requires energy, in the form of sunlight, to split one water molecule into one-half of an oxygen molecule (O2; the oxidizing agent) and two hydrogen atoms (H; the reducing agent), each of which dissociates to one hydrogen ion (H+) and one electron. Through a series of oxidation-reduction reactions, electrons (denoted e) are transferred from a donating molecule (oxidation), in this case water, to an accepting molecule (reduction) by a series of chemical reactions; this “reducing power” may be coupled ultimately to the reduction of carbon dioxide to the level of carbohydrate. In effect, carbon dioxide accepts and bonds with hydrogen, forming carbohydrates (Cn[H2O]n).

Living organisms that require oxygen reverse this process: they consume carbohydrates and other organic materials, using oxygen synthesized by plants to form water, carbon dioxide, and energy. The process that removes hydrogen atoms (containing electrons) from the carbohydrates and passes them to the oxygen is an energy-yielding series of reactions.

In plants, all but two of the steps in the process that converts carbon dioxide to carbohydrates are the same as those steps that synthesize sugars from simpler starting materials in animals, fungi, and bacteria. Similarly, the series of reactions that take a given starting material and synthesize certain molecules that will be used in other synthetic pathways are similar, or identical, among all cell types. From a metabolic point of view, the cellular processes that take place in a lion are only marginally different from those that take place in a dandelion.

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