So if it’s common for people to have expired injectable epinephrine kits, would it be OK to use them for the treatment of anaphylaxis? This exact question was studied by a group of researchers in Canada and published in the year 2000.
The group collected expired EpiPens and determined the potency of the epinephrine contained within them. The potency of the epinephrine was determined by two methods: Taking blood samples from rabbits after they were injected with the expired EpiPens, as well as performing chemical tests on the residual amount of solution left in the EpiPens after they were used. The measurements found in the expired EpiPens were compared to measurements from non-expired EpiPens.
While both methods studied showed that the expired EpiPens contained less epinephrine compared to the non-expired EpiPens, there was still a surprisingly high amount of epinephrine in the expired EpiPens.