3. Drugs acting on cardiovascular system

3. Potassium Channel Openers

Nicorandil acts in three ways:

  1. Releases NO leading to vasodilatation, decreasing preload and afterload
  2. Hyperpolarization, leading to relaxation of blood vessels
  3. Helps by virtue of preconditioning of myocardium. The myocardium contains K+ channels (ATP gated) also found n pancreas associated with insulin release. They reduce overloading of Ca++ reducing contractility, this is called reconditioning.

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