Gene Structure – This is the most important factor when it comes to cell differentiation. Each of the viable genes contains important information that determine the cell type and physical attributes of the animal (host). Any problem in the genetic material ultimately affects cell differentiation and the development of the host.
Environmental Factors – Various environmental factors as changes in temperature and supply of oxygen etc can affect the release and production of hormones given that various proteins are involved in the transmission of information as well as triggering of hormones. If these molecules are affected, then cell differentiation and development is also affected.