Silvadene cream

Side Effects

Some side effects are associated with Silvadene, and they can range from mild to serious. If you have bothersome symptoms that persist, talk with your healthcare provider so they can evaluate whether you should continue using the cream or switch to another method. The side effects can range from common (and mild) to severe:


Common side effects may include::

  • Burning sensations
  • Itchy skin
  • Pain
  • Skin discoloration


Serious side effects are uncommon with Silvadene. Contact your healthcare provider as soon as possible if you experience:

  • Blood in your urine
  • Fatigue
  • Fever
  • Joint aches and pains
  • (New) rash on the skin
  • Sore throat
  • Unexplained bruising or bleeding
  • Weakness
  • Yellowing of the eyes or skin

Additionally, Silvadene poses a slight risk for leukopenia—a decrease in white blood cells (WBCs). Research shows that the onset of leukopenia tends to happen two to four days after treatment begins, with a recovery of the white blood cells occurring two or three days after the initial drop or once the drug is discontinued. Leukopenia caused by the use of Silvadene doesn’t increase the risk of infections or affect treatment outcomes.

No Babies Allowed

Silvadene cream is not recommended for premature babies, newborn babies, or children 2 months old or younger.

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