As mentioned previously, most of the time, the blister will heal on its own as long as you remove the trauma or repetitive movement that initially caused it.
If your blister causes discomfort, over-the-counter pain relievers like ibuprofen or acetaminophen may be sufficient to ease the pain.
Although you may be tempted to pop the blood blister, experts recommend resisting the urge to do so. The layer of skin that covers the blister helps protect it from infection. Over time—about one to two weeks—the blood blister should dry up on its own.