There isn’t a clear-cut best antibiotic for skin boils. Some antibiotics may work better than others in clearing a particular bacterium that causes a skin boil. For example, trimethoprim-sulfamethoxazole, clindamycin, and minocycline are more successful in treating an MRSA infection. But skin boils caused by non-MRSA conditions can usually be treated with antibiotics like amoxicillin, cephalosporins, and dicloxacillin.
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